Media Advisory
Monday, August 31, 2020
NIH-funded study provides hope for better disease prediction.
What:
An international team of scientists supported by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health, has identified a novel association between the gene FAF2 and a reduced risk for alcohol-associated liver cirrhosis (ALC) in people who drink heavily. Also confirmed by the study were four additional genes, three previously found to be associated with an increased risk and one with reduced risk of ALC in people who drink heavily. All of the genes appear to be involved in fat metabolism in the liver. ALC is a major source of alcohol–related morbidity and mortality worldwide. Taken together, the new findings help solidify our understanding of ALC, particularly with regard to the connection between fat metabolism and vulnerability to cirrhosis. Genetic risk factors combined with clinical and phenotype risks, offers the potential for improved disease prediction and the realization of the promise of personalized medicine.
Article:
T-W Schwantes-An, et al. Genome-wide association study and meta-analysis on alcohol-related liver cirrhosis identifies novel genetic risk factors. Hepatology (published online Aug. 28, 2020).
Who:
NIAAA Director George F. Koob, Ph.D., is available to comment on this research.
Funding:
This research was funded by NIAAA grant U01- AA018389 to support an international research consortium — the GenomALC – the largest genome-wide association study of alcohol-related cirrhosis conducted to date. Additional support was provided by the Swiss National Funds and the Swiss Foundation for Alcohol Research, and the National Health & Medical Research Council of Australia.
About the National Institute on Alcohol Abuse and Alcoholism (NIAAA): The National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health, is the primary U.S. agency for conducting and supporting research on the causes, consequences, diagnosis, prevention, and treatment of alcohol use disorder. NIAAA also disseminates research findings to general, professional, and academic audiences. Additional alcohol research information and publications are available at https://www.niaaa.nih.gov/.
About the National Institutes of Health (NIH):
NIH, the nation’s medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.
NIH…Turning Discovery Into Health®
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I was recommended this website by my cousin. I am not sure whether this post is written by him as nobody else know such detailed about my difficulty. You are wonderful! Thanks!
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I do not even know how I ended up here, but I thought this post was great. I don’t know who you are but definitely you’re going to a famous blogger if you aren’t already 😉 Cheers!
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I was recommended this website by my cousin. I am not sure whether this post is written by him as nobody else know such detailed about my trouble. You are amazing! Thanks!
Hello, Neat post. There’s an issue together with your site in internet explorer, would check this텶E still is the marketplace chief and a large element of other folks will leave out your magnificent writing due to this problem.
Hello, i think that i saw you visited my weblog so i came to ?eturn the favor텶’m trying to find things to improve my web site!I suppose its ok to use some of your ideas!!
obviously like your web-site but you need to test the spelling on quite a few of your posts. Several of them are rife with spelling problems and I to find it very troublesome to inform the reality on the other hand I’ll certainly come back again.
I do trust all the ideas you’ve presented in your post. They are really convincing and will definitely work. Nonetheless, the posts are too short for newbies. May just you please lengthen them a bit from next time? Thank you for the post.
I have been surfing online more than 3 hours today, yet I never found any interesting article like yours. It is pretty worth enough for me. In my opinion, if all web owners and bloggers made good content as you did, the web will be much more useful than ever before.
Wonderful beat ! I wish to apprentice while you amend your web site, how could i subscribe for a blog web site? The account aided me a acceptable deal. I had been a little bit acquainted of this your broadcast provided bright clear idea
I loved as much as you’ll receive carried out right here. The sketch is attractive, your authored material stylish. nonetheless, you command get bought an nervousness over that you wish be delivering the following. unwell unquestionably come more formerly again as exactly the same nearly a lot often inside case you shield this hike.
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Thank you, I have just been searching for information approximately this topic for a while and yours is the best I have found out so far. However, what in regards to the bottom line? Are you certain concerning the supply?
My brother suggested I might like this website. He was totally right. This post actually made my day. You cann’t imagine just how much time I had spent for this information! Thanks!
Hi, i think that i saw you visited my web site thus i came to ?eturn the favor텶 am attempting to find things to improve my web site!I suppose its ok to use some of your ideas!!
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Excellent blog here! Also your website loads up very fast! What web host are you using? Can I get your affiliate link to your host? I wish my web site loaded up as quickly as yours lol
I just could not leave your web site before suggesting that I really enjoyed the standard information a person supply to your visitors? Is gonna be again steadily in order to check up on new posts.
I just could not leave your web site before suggesting that I really enjoyed the standard information a person supply to your visitors? Is gonna be again steadily in order to check up on new posts.
Thank you for the good writeup. It in fact was a amusement account it. Look advanced to far added agreeable from you! However, how could we communicate?
I do believe all the ideas you’ve presented for your post. They are really convincing and will certainly work. Nonetheless, the posts are too short for novices. May just you please lengthen them a little from subsequent time? Thanks for the post.
I am not sure where you’re getting your info, but good topic. I needs to spend some time learning much more or understanding more. Thanks for magnificent info I was looking for this information for my mission.
Thank you for the auspicious writeup. It in fact was a amusement account it. Look advanced to more added agreeable from you! By the way, how could we communicate?
Excellent blog here! Also your website loads up very fast! What web host are you using? Can I get your affiliate link to your host? I wish my web site loaded up as quickly as yours lol
Magnificent beat ! I would like to apprentice while you amend your site, how can i subscribe for a blog web site? The account helped me a acceptable deal. I had been a little bit acquainted of this your broadcast offered bright clear idea
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What i don’t understood is in reality how you’re now not really a lot more smartly-favored than you might be now. You’re very intelligent. You understand therefore significantly in terms of this topic, produced me personally believe it from a lot of numerous angles. Its like women and men are not interested except it is one thing to accomplish with Woman gaga! Your own stuffs outstanding. Always care for it up!
Simply desire to say your article is as surprising. The clearness in your post is simply excellent and i could assume you are an expert on this subject. Fine with your permission let me to grab your feed to keep up to date with forthcoming post. Thanks a million and please carry on the gratifying work.
I do agree with all the ideas you have introduced on your post. They are very convincing and will definitely work. Still, the posts are very short for newbies. May just you please prolong them a little from subsequent time? Thank you for the post.
Simply wish to say your article is as amazing. The clearness in your post is just nice and i could assume you’re an expert on this subject. Well with your permission let me to grab your feed to keep updated with forthcoming post. Thanks a million and please carry on the gratifying work.
I loved as much as you will receive carried out right here. The sketch is tasteful, your authored subject matter stylish. nonetheless, you command get got an edginess over that you wish be delivering the following. unwell unquestionably come further formerly again as exactly the same nearly very often inside case you shield this hike.
My brother recommended I might like this web site. He was totally right. This post actually made my day. You cann’t imagine just how much time I had spent for this information! Thanks!
Thank you for the auspicious writeup. It in fact was a amusement account it. Look advanced to more added agreeable from you! By the way, how could we communicate?
Fantastic site. A lot of helpful info here. I’m sending it to some buddies ans additionally sharing in delicious. And naturally, thanks on your sweat!
certainly like your website but you need to take a look at the spelling on quite a few of your posts. Many of them are rife with spelling problems and I find it very troublesome to inform the reality nevertheless I will definitely come back again.
Hi, Neat post. There’s an issue together with your web site in internet explorer, may test this텶E still is the marketplace chief and a good component of people will pass over your fantastic writing due to this problem.
I do not even know how I ended up here, but I thought this post was great. I don’t know who you are but definitely you’re going to a famous blogger if you aren’t already 😉 Cheers!
Hello, i think that i saw you visited my weblog so i came to ?eturn the favor텶’m trying to find things to improve my web site!I suppose its ok to use some of your ideas!!
I have been browsing online more than three hours today, yet I never found any interesting article like yours. It is pretty worth enough for me. In my view, if all website owners and bloggers made good content as you did, the internet will be a lot more useful than ever before.
I have been browsing online more than three hours today, yet I never found any interesting article like yours. It is pretty worth enough for me. In my view, if all website owners and bloggers made good content as you did, the internet will be a lot more useful than ever before.
Its like you read my mind! You appear to know so much about this, like you wrote the book in it or something. I think that you can do with a few pics to drive the message home a little bit, but instead of that, this is excellent blog. A fantastic read. I’ll certainly be back.
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